Having a light snack before bedtime is OK, but eating too much may cause you to feel physically uncomfortable while lying down. Computers, TVs, video games, smartphones or other screens just before bed can interfere with your sleep cycle. Poor sleep habits include an irregular bedtime schedule, naps, stimulating activities before bed, an uncomfortable sleep environment, and using your bed for work, eating or watching TV. Causes include jet lag from traveling across multiple time zones, working a late or early shift, or frequently changing shifts. Disrupting your body's circadian rhythms can lead to insomnia. Your circadian rhythms act as an internal clock, guiding such things as your sleep-wake cycle, metabolism and body temperature. Stressful life events or trauma - such as the death or illness of a loved one, divorce, or a job loss - also may lead to insomnia. Concerns about work, school, health, finances or family can keep your mind active at night, making it difficult to sleep. Treating the underlying cause can resolve the insomnia, but sometimes it can last for years.Ĭommon causes of chronic insomnia include: Effects of lemborexant did not diminish over the period of the study and adverse effects due to treatment were mild to moderate and consisted of effects such as mild sleep paralysis, headache, and daytime sleepiness.Insomnia may be the primary problem, or it may be associated with other conditions.Ĭhronic insomnia is usually a result of stress, life events or habits that disrupt sleep. Most participants using lemborexant fell asleep within 20 minutes and slept more than 60 minutes longer than they had before treatment, which is an important clinical improvement. Subjective measures for how long participants thought they slept did not differ between the two types of medication. It was significantly more effective than extended-release zolpidem for decreasing the time to fall asleep but not for decreasing the time awake after sleep onset. Over the course of the study, lemborexant demonstrated significant decreases in the time to fall asleep and in the amount of time awake during the night as compared to placebo at both dose levels considered. The participants were essentially equally divided into groups between the two dosage levels for lemborexant, the one dosage level for zolpidem, and a placebo. I have not had reports of side effects such as sleep paralysis in any patients using this medication with whom I have worked. To date, I have worked with patients who found it effective and with patients for whom the benefits were minimal. It is also unclear if it is safe for use by people with addiction histories, as there is potential for dependency. Consumer Reports had actually recommended against the use of suvorexant because users have only small improvements in quantity of sleep, can have next day hangover, may have hallucinations or sleep paralysis, can have next-day impairment of complex skills such as driving, and it is more expensive than already existing generic medications. Lemborexant works on the same brain areas as suvorexant but may have fewer side effects. They work by inhibiting the wake-promoting effects of the neurotransmitter orexin (Bennett, Bray, & Neville, 2014). Suvorexant was the first of a new class of sleeping medications known as orexin receptor antagonists.
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